In 1856, Franklin Pierce wanted a second term as president. However his southern sympathies made him extremely unpopular in the north even among his own party. He lost the nomination as the Democratic Party nominee, making it the only time in American political history this is happened to an incumbent president
I am not familiar with him at all and about 12 books away from reading about him:)
Republicans should have done it this year.
Agree with the comment above:D